Dipeptides

L-α-dipeptide (dipeptide) ntabwo yigeze yigwa hafi nkuko ifite proteyine na aside amine.Ubushakashatsi bwibanze bwakozwe kuri L-aspartyl-L-phenylalanine methylester (aspartame) na Ala-Gln (Lalanyl-L-glutamine) kuko bikoreshwa mubicuruzwa bizwi cyane mubucuruzi.Usibye uku kuri, indi mpamvu yatumye dipeptide nyinshi itigwa neza ni ukubera ko umusaruro wa dipeptide udafite uburyo bwiza bwo kubyaza umusaruro, nubwo hari uburyo bwinshi bwa chimique na chemoenzymatique.

Carnosine - urugero rwa dipeptide
Kugeza vuba aha, uburyo bushya bwateguwe kuri synthesis ya dipeptide ya dipeptide ikorwa hakoreshejwe uburyo bwa fermentative.Dipeptide zimwe na zimwe zifite ubushobozi bwihariye bwa physiologique, zibemerera kwihutisha ikoreshwa rya dipeptide mubice bitandukanye byubushakashatsi bwa siyansi.L.Dipeptide, ariko, ifite imikorere ishimishije cyane, kandi amakuru yubumenyi ayakikije ariyongera.Ibi bisiga abashakashatsi benshi bashinzwe guteza imbere uburyo bunoze kandi buhendutse bwo gukora dipeptide.Iyo uyu murima wizwe neza, biteganijwe ko dushobora kwiga byinshi kubyerekeranye nuburyo peptide ifite agaciro.

Dipeptide ifite ibikorwa bibiri by'ibanze, aribyo:
1. Inkomoko ya aside amine
2. Dipeptide ubwayo

Nkibikomoka kuri aside amine, dipeptide, hamwe na acide ya amine irimo ibintu bitandukanye bya physiochemiki, ariko mubisanzwe bigira ingaruka zimwe mumubiri.Ni ukubera ko dipeptide yangirika muri aside amine itandukanye mu binyabuzima, bifite imiterere itandukanye ya fiziki.Kurugero, L-glutamine (Gln) ni ubushyuhe-labile, mugihe Ala-Gin (L-alanyl-L-glutamine) yihanganira ubushyuhe.

Sintezike yimiti ya dipeptide ibaho kuburyo bukurikira:
1. Amatsinda yose ya dipeptide akora ararinzwe (usibye nayagize uruhare mukurema peptide ya aside amine acide).
2. Acide irinzwe ya acide yubusa ya carboxyl ikora.
3. Acide amino ikora ikora hamwe nizindi aside irinzwe.
4. Amatsinda yo kurinda akubiye muri dipeptide avanwaho.